Devon and Cornwall Police said in a statement: "Police were called to a serious firearms incident in Biddick Drive, in the Keyham area of Plymouth at around 6.10pm today.
There have been a "number of fatalities" and "several" other casualties are receiving treatment following a "serious firearms incident" in Plymouth, Devon and Cornwall police say.
Four victims were found dead at the scene, while a fifth died a short time later in hospital.
A shooter involved in the incident has been shot and is believed to be dead, Sky news' Mark White has been told.
It is not being treated as terror-related and the incident, in the Keyham area, is believed to have been contained.
"Officers and ambulance staff attended. There have been a number of fatalities at the scene and several other casualties are receiving treatment.
"A critical incident has been declared. The area has been cordoned off and police believe the situation is contained."
Home secretary Priti Patel tweeted: "The incident in Plymouth is shocking and my thoughts are with those affected.
"I have spoken to the Chief Constable and offered my full support.
"I urge everyone to remain calm, follow police advice and allow our emergency services to get on with their jobs."
Plymouth Sutton and Devonport MP Luke Pollard said it was "a very grim day for our city and our community".
The Labour frontbencher said he was "awaiting confirmation" of the number of victims.
Plymouth Moor View MP Johnny Mercer also said on Twitter that the incident is "not terror related", adding that the suspect involved is "not on the run".
In an earlier tweet he added: "Please obey all instructions from the police and do not post rumour or speculation on social media."
Southwestern Ambulance Service said "Hazardous Area Response Teams (HART), multiple ambulances, air ambulances, multiple doctors and senior paramedics" were all sent to the scene of an ongoing incident at 6.12pm.
Multiple police vehicles have been seen in the area.
Devon and Cornwall Police have been contacted for more information.

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