Facing pressure over media reports suggesting the lockdown would be eased, the foreign secretary said that reports were "not a reliable guide" to future policy decisions.
The PM says the government will proceed with "maximum caution" when considering easing coronavirus restrictions.
Boris Johnson is due to announce plans for England's lockdown on Sunday, but ministers have insisted short term changes to measures will be "modest".
At the government's daily briefing, Foreign Secretary Dominic Raab described media reports on easing restrictions as "not a reliable guide".
He added that changes may vary between the different nations.
It comes after Scotland's lockdown was formally extended and the Northern Ireland Executive said there was "no headroom" yet to ease the lockdown.
Wales is due to announced its the nation's lockdown plans on Friday, after the Welsh government warned media reports speculating how Mr Johnson might ease lockdown measures risked sending "mixed messages" to the public.
Some newspapers suggested the rules on exercise could be relaxed and more people encouraged to return to work.
Scotland, Wales and Northern Ireland have the power to make their own decisions on lockdown regulations - and could lift restrictions at a different rate.
The prime minister has told leaders of the devolved nations that he is committed to a UK-wide approach to tackling coronavirus "even if different parts of the UK begin to move at slightly different speeds", Downing Street said.
"Those decisions will be made based on the science for each nation," a No 10 spokesman added.
The latest figures show the total number of people who have died in hospitals, care homes and the wider community in the UK after testing positive for coronavirus is 30,615 - a daily increase of 539.
The UK provided some 86,583 tests in 24 hours to 09:00 BST on Thursday - meaning the government missed its 100,000-per-day target for the fifth consecutive day.
At the briefing, Mr Raab said any short term changes to restrictions would be "modest, small, incremental and very carefully monitored".
He stressed that the existing rules would still apply over the bank holiday weekend and urged people to "continue to follow the guidance".
He added that future decisions would be based on the reproduction number - known as the R level - which represents the average number of people that an infected person will pass the virus on to.
"If we find in the future the R level goes back up or that people aren't following the rules, we must have the ability then to put back measures in place," he said.
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