This might be the end to malaria infection as the first malaria vaccine candidate to reach phase-3 of clinical testing.
Giving the hint about this
development yesterday, Brian Greenwood, corresponding author and Professor of
Clinical Tropical Medicine at London School of Hygiene & Tropical Medicine
in the UK, explained that results of the tests suggested that the vaccine
candidate known as RTS, S/AS01 could prevent a substantial number of cases of
clinical malaria, especially in areas of high transmission.
Greenwood noted that the
European Medicines Agency, EMA, will “assess the quality, safety, and efficacy
of the vaccine based on these final data. There is currently no licensed
vaccine against malaria anywhere in the world.”
If the EMA gives a
favourable opinion, the World Health Organisation could recommend the use of
RTS,S/AS01 as early as October this year. If licensed, RTS,S/AS01 would be the
first licensed human vaccine against a parasitic disease,” Greenwood added.
The findings, published in
the journal, The Lancet, revealed that vaccine efficacy against clinical and
severe malaria was better in children than in young infants, but waned over
time in both groups.
However, protection was
prolonged by a booster dose, increasing the average number of cases prevented
in both children and young infants.
Further, Greenwood argued
that despite the falling efficacy over time, there is still a clear benefit
from RTS,S/AS01.
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